Preventive treatment to significantly reduce your risk of heart attack or stroke

What is the Polypill Prevention Programme?

The Polypill Prevention Programme includes a daily preventive treatment consisting of carefully selected medicines combined at the right doses to have a major impact on preventing heart attacks and strokes with minimal risk of side effects. Read below to find out about the Polypill Prevention Programme and see our page about How it works.

What's in the treatment offered?

The treatment provided as part of the Polypill Prevention Programme is designed for maximum effectiveness and minimum side effects. It should be taken daily, ideally in the evening. The treatment contains the following:

Name                             Dose                    What is it?



Simvastatin is a common well trialled medication which, at this dose, decreases the amount of LDL cholesterol in the blood by 34%1



Hydrochlorothiazide has also commonly been used for many years. It lowers the blood pressure and helps eliminate excess sodium. In order to reduce the chance of side effects, half the standard dose is used.



Losartan is an angiotensin receptor blocking (ARB) drug, reducing the body's response to angiotensin II which increases blood pressure. This helps to protect organs such as the heart and kidneys from the harmful effects of blood pressure. Half the standard dose is used.



Amlodipine is a calcium channel blocking (CCB) drug which reduces blood pressure that has been widely used for many years. Half the standard dose is used.

The medication we provide within the programme is manufactured by an MHRA approved UK licenced manufacturer. We provide a treatment which contains individual components that are licensed for the reduction of serum cholesterol or blood pressure. It can be made available, if appropriate, following a medical consultation.

Free online consultation with our doctors

Our doctors are able to assess your suitability for joining the Polypill Prevention Programme through an online consultation. If suitable, you can then place an order via our secure website. An order will result in a prescription which allows our partner pharmacy to dispense your medication. If you would like to discuss the Polypill Prevention Programme with your GP first, please do so. We provide more information for other doctors here.

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Backed by leading institutions and experts

The Polypill Prevention Programme is a powerful example of preventive medicine. All the Polypill Prevention Programme treatment components have been widely used to treat people with cardiovascular disease. The objective is to prevent these diseases from arising in the first place. By using the right combination of medicines, the risk of a heart attack and stroke can be reduced by two thirds. The basis for this strategy was set out in a series of papers and journals.

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